Etanercept shows promise for treating dermatomyositis
A multicenter pilot study of etanercept for treatment of dermatomyositis found no major safety concerns and many patients treated with the drug were successfully weaned from steroid therapy. These...
View ArticleCommon rheumatoid arthritis and psoriasis medications are associated with...
Individuals with systemic inflammatory conditions, such as rheumatoid arthritis (RA) and psoriasis, experience a 1.5 to 2-fold increased rate of cardiovascular disease. Previous research suggests that...
View ArticleCertain biologic therapies for psoriasis do not appear to increase risk for...
Although some preliminary reports have indicated an increased risk of major adverse cardiovascular events with the use of certain biologic therapies to treat chronic plaque psoriasis, an analysis of...
View ArticleT cells making brain chemicals may lead to better treatments for...
Scientists have identified a surprising new role for a new type of T cell in the immune system: some of them can be activated by nerves to make a neurotransmitter (acetylcholine) that blocks...
View ArticleTuberculosis bacterium's outer cell wall disarms the body's defense to remain...
The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the...
View ArticleMushroom compound appears to improve effectiveness of cancer drugs
A compound isolated from a wild, poisonous mushroom growing in a Southwest China forest appears to help a cancer killing drug fulfill its promise, researchers report.
View ArticleRecipient's immune system governs stem cell regeneration
A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance...
View ArticleScientists identify cell death pathway involved in lethal sepsis
Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Sepsis is linked with massive cell death; however, the specific mechanisms involved in the lethality...
View ArticlePreviously unconnected molecular networks conspire to promote cancer
An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The...
View ArticleStudy identifies novel markers as key indicators of future renal failure in...
Scientists at Joslin Diabetes Center have identified two novel markers that, when elevated in the blood stream, can predict accurately the risk of renal (kidney) failure in patients with Type 1 and...
View ArticlePossible new pathway can overcome glioblastoma resistance
Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months.
View ArticleDual mode laser therapy effectively treats acne vulgaris
(HealthDay) -- A series of Nd:YAG laser treatments effectively and rapidly reduces both inflammatory and noninflammatory acne vulgaris lesions, according to a study published in the April issue of the...
View ArticleEtanercept - genetically engineered compound for back pain - falls short: study
Despite the great promise that injecting a new type of anti-inflammatory pain medicine into the spine could relieve the severe leg and lower back pain of sciatica, a Johns Hopkins-led study has found...
View ArticleIL-32 expression upregulated in chronic rhinosinusitis
(HealthDay) -- Interleukin-32 (IL-32) mRNA expression is significantly higher in biopsies obtained from patients with chronic rhinosinusitis (CRS), compared to levels found in biopsies obtained from...
View ArticleBio-hybrid device acts as 'thermostat' to control systemic inflammation in...
A small, external bioreactor holding human cells pumped out an anti-inflammatory protein to prevent organ damage and other complications in a rat with acute inflammation caused by bacterial products in...
View ArticleFactors ID'd in healing failure of diabetic foot ulcers
(HealthDay) -- Patients with diabetes whose foot ulcers fail to heal have increased inflammation and aberrant growth factor levels, according to a study published online June 11 in Diabetes.
View ArticleHep B screening urged before TNF-alpha inhibitor therapy
(HealthDay) -- All patients with psoriasis should be screened for hepatitis B surface antigen and hepatitis B core antibody prior to the initiation of tumor necrosis factor-alpha inhibitor therapy,...
View ArticleObesity is a risk factor for poor remission rates in RA
(HealthDay) -- For patients with long-standing rheumatoid arthritis treated with anti-tumor necrosis factor-α (anti-TNFα) therapies, obesity is related to poor remission rates, according to a study...
View ArticleSome harmful effects of light at night can be reversed: study
Chronic exposure to dim light at night can lead to depressive symptoms in rodents -- but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.
View ArticleResearchers discover molecular link between circadian clock disturbances and...
Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more...
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